Article
Molecular Discordance between Myeloid Sarcomas and Concurrent Bone Marrows Occurs in Actionable Genes and Is Associated with Worse Overall Survival.
The Journal of molecular diagnostics : JMD - 1 Mar 2020
Werstein Brian, Dunlap Jennifer, Cascio Michael J, Ohgami Robert S, Fan Guang, Press Richard, Raess Philipp W
Abstract excerpt
Myeloid sarcoma is a rare, architecture-effacing proliferation of myeloid blasts localized to an extramedullary site, with or without concurrent bone marrow involvement. Clonal heterogeneity results from acquisition of somatic mutations within different subclones of leukemic cells. It was hypothesized that clonal heterogeneity between myeloid sarcomas and concurrent bone marrow biopsies might be present, given...
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