Article

Direct delivery of stabilized Cas-embedded base editors achieves efficient and accurate editing of clinically relevant targets

2024-02-08

Abstract excerpt

Over the last 5 years, cytosine base editors (CBEs) have emerged as a promising therapeutic tool for specific editing of single nucleotide variants and disrupting specific genes associated with disease. Despite this promise, the currently available CBE’s have the significant liabilities of off-target and bystander editing activities, in part due to the mechanism by which they are delivered, causing limitations in...

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Literature Corpus work: daf51104-efc0-5296-ad55-5f35cf6d359f
DOI: 10.1101/2024.02.08.579528

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