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Article

Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer.

Science advances - 1 Jun 2016

Singhal Hari, Greene Marianne E, Tarulli Gerard, Zarnke Allison L, Bourgo Ryan J, Laine Muriel, Chang Ya-Fang, Ma Shihong, Dembo Anna G, Raj Ganesh V, Hickey Theresa E, Tilley Wayne D, Greene Geoffrey L

Abstract excerpt

The functional role of progesterone receptor (PR) and its impact on estrogen signaling in breast cancer remain controversial. In primary ER(+) (estrogen receptor-positive)/PR(+) human tumors, we report that PR reprograms estrogen signaling as a genomic agonist and a phenotypic antagonist. In isolation, estrogen and progestin act as genomic agonists by regulating the expression of common target genes in similar...

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Identifiers

PMID: 27386569
DOI: 10.1126/sciadv.1501924
PMCID: PMC4928895

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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