Article

In situ vaccine effect of radiotherapy is associated with intratumoural ERV transcription and RNA virus sensing

2026-02-09

Abstract excerpt

Radiotherapy (RT) transforms tumour tissues into in situ vaccines that trigger antitumor immunity. Immunogenicity depends on how RT is delivered, since heterogeneous RT (spatially fractionated RT, SFRT) elicits more prominent responses than the conventional homogenous one. However, this phenomenon cannot be clinically harnessed, unless the relevant pathways are identified. To gain insights, we developed a hybrid...

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Literature Corpus work: 090b1fe4-18b4-5ca4-869b-c88d3a2b5007
DOI: 10.64898/2026.02.06.704391

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