Article

Complement C3 vs C5 inhibition in severe COVID-19: early clinical findings reveal differential biological efficacy

2020-08-21

Abstract excerpt

Growing clinical evidence has implicated complement as a pivotal driver of COVID-19 immunopathology. Deregulated complement activation may fuel cytokine-driven hyper-inflammation, thrombotic microangiopathy and NET-driven immunothrombosis, thereby leading to multi-organ failure. Complement therapeutics have gained traction as candidate drugs for countering the detrimental consequences of SARS-CoV-2 infection. Whet...

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Literature Corpus work: 9b7adfcf-543e-519d-917d-fb8ee5f7454b
DOI: 10.1101/2020.08.17.20174474

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