Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders.

Abstract excerpt

Recent studies show that the complex genetic architecture of schizophrenia (SZ) is driven in part by polygenic components, or the cumulative effect of variants of small effect in many genes, as well as rare single-locus variants with large effect sizes. Here we discuss genetic aberrations known as copy number variants (CNVs), which fall in the latter category and are associated with a high risk for SZ and other...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromosome Deletion
• Share to Chromosomes, Human, Pair 3