Article
Microdeletions of 3q29 confer high risk for schizophrenia.
American journal of human genetics - 13 Aug 2010
Mulle Jennifer Gladys, Dodd Anne F, McGrath John A, Wolyniec Paula S, Mitchell Adele A, Shetty Amol C, Sobreira Nara L, Valle David, Rudd M Katharine, Satten Glen, Cutler David J, Pulver Ann E, Warren Stephen T
Abstract excerpt
Schizophrenia (SZ) is a severe psychiatric illness that affects approximately 1% of the population and has a strong genetic underpinning. Recently, genome-wide analysis of copy-number variation (CNV) has implicated rare and de novo events as important in SZ. Here, we report a genome-wide analysis of 245 SZ cases and 490 controls, all of Ashkenazi Jewish descent. Because many studies have found an excess burden of...
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