Article
FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans.
Cell metabolism - 2 May 2017
Søberg Susanna, Sandholt Camilla H, Jespersen Naja Z, Toft Ulla, Madsen Anja L, von Holstein-Rathlou Stephanie, Grevengoed Trisha J, Christensen Karl B, Bredie Wender L P, Potthoff Matthew J, Solomon Thomas P J, Scheele Camilla, Linneberg Allan, Jørgensen Torben, Pedersen Oluf, Hansen Torben, Gillum Matthew P, Grarup Niels
Abstract excerpt
The liking and selective ingestion of palatable foods-including sweets-is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we...
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