Mammalian Neuraminidase-1 is a Critical Target of Thromboxane Induced T-Cell Immunosuppression

Abstract excerpt

Aspirin or celecoxib in combination with chemotherapy significantly reduced the risk for disease recurrence and improved survival after colorectal cancer surgery in the approximately 20% of patients harbouring activating mutations in the PIK3CA gene 1-3 . The biological mechanisms behind the anti-cancer effects of these medications are an area of intense research interest. Recently, Yang et al. 4 found that pla...

Topics

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• Anti-Inflammatory Agents, Non-Steroidal
• Aspirin
• Chemokine CCL2
• Chemokine CXCL10
• Cyclooxygenase 2 Inhibitors
• Dinoprostone
• Inflammatory mediators and NSAID effects
• Lysosomal-Associated Membrane Protein 1

Identifiers and source

Literature Corpus work

da3eac67-fb3d-57b7-bae0-b5b5f61150ce

DOI

10.64898/2025.12.01.691391