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Article

Role of Leptin Deficiency, Inefficiency, and Leptin Receptors in Obesity.

Biochemical genetics - 1 Oct 2016

Wasim Muhammad, Awan Fazli Rabbi, Najam Syeda Sadia, Khan Abdul Rehman, Khan Haq Nawaz

Abstract excerpt

Leptin protein consists of 167 amino acids, which is mainly secreted from the white adipose tissue. This protein acts on the hypothalamic regions of the brain which control eating behavior, thus playing a significant role in maintaining body's metabolism. Leptin receptors belong to glycoprotein 130 (gp130) family of cytokine receptors and exist in six isoforms (LEPR a-f), and all the isoforms are encoded by LEPR...

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LEP gene
LEPR gene
Genetic Predisposition to Disease
Leptin
Mutation

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Receptors, Leptin

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PMID: 27313173
DOI: 10.1007/s10528-016-9751-z

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LEPR
LEP

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