Article
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis.
Molecular cancer - 30 Mar 2022
Limberger Tanja, Schlederer Michaela, Trachtová Karolina, Garces de Los Fayos Alonso Ines, Yang Jiaye, Högler Sandra, Sternberg Christina, Bystry Vojtech, Oppelt Jan, Tichý Boris, Schmeidl Margit, Kodajova Petra, Jäger Anton, Neubauer Heidi A, Oberhuber Monika, Schmalzbauer Belinda S, Pospisilova Sarka, Dolznig Helmut, Wadsak Wolfgang, Culig Zoran, Turner Suzanne D, Egger Gerda, Lagger Sabine, Kenner Lukas
Abstract excerpt
BACKGROUND: Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C have been detected by whole exome sequencing studies in various cancers, including malignancies of the prostate. However, the biological consequences of these alterations in prostate cancer have not yet been elucidated. METHODS: To investigate the functional effects of these mutations, we deleted the C-terminal catalytic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.