Article

Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias

2021-01-16

Abstract excerpt

The Hereditary Spastic Paraplegias are a group of neurodegenerative diseases characterized by spasticity and weakness in the lower body. Despite the identification of causative mutations in over 70 genes, the molecular aetiology remains unclear. Due to the combination of genetic diversity and variable clinical presentation, the Hereditary Spastic Paraplegias are a strong candidate for protein-protein interaction n...

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Literature Corpus work: d9e0ded5-146b-5ab6-8dcf-f26b62ebdf0e
DOI: 10.1101/2021.01.14.425874

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