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Article

Unraveling the molecular mechanisms of ALS: a network biology and structural modeling approach of investigating the impact of C9orf72 mutations.

Journal of biomolecular structure & dynamics - 1 Feb 2026

Alzahrani A Khuzaim, A S Alshrari, Imran Mohd

Abstract excerpt

C9orf72 is a major genetic factor in Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disorder affecting brain and spinal cord neurons, and comprehending its mutational impact is crucial for developing ALS therapies. Therefore, the current study's protein-protein interaction (PPI) network for C9orf72 was meticulously mapped to identify key interactors that might influence the disease mechanism. Among the...

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Identifiers

PMID: 39659205
DOI: 10.1080/07391102.2024.2437682

Genes

SMCR8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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