Neutrophil extracellular traps-associated candidate genes in IgA vasculitis: an exploratory multi-omics analysis integrating transcriptomics and Mendelian randomization.

Abstract excerpt

OBJECTIVE: Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of IgA vasculitis (IgAV), yet the NET-associated genes and their immune cell-specific contexts remain incompletely defined. This study aimed to exploratorily identify NET-associated candidate genes related to IgAV using an integrated multi-omics approach. METHODS: Peripheral-blood bulk transcriptomic data from IgAV patients...

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