Article

Nervous Necrosis Virus Capsid Protein Functions as a SUMO E3 Ligase to Activate MAVS-Dependent NF-κB Signaling

2025-05-29

Abstract excerpt

Nervous necrosis virus (NNV) is a lethal aquatic pathogen that activates NF-κB signaling to manipulate host immune responses, yet the underlying molecular mechanisms remain poorly defined. Here, we identify the NNV capsid protein (CP) as a novel viral SUMO E3 ligase that promotes SUMOylation of Lateolabrax japonicus mitochondrial antiviral signaling protein (MAVS) to drive NF-κB activation. We show that CP induce...

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Literature Corpus work: d98c30ed-a8af-5a09-b8b8-a7e8250a497c
DOI: 10.1101/2025.05.29.656765

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