Article

Exogenous BMP9 therapy ameliorates primary graft dysfunction post lung transplantation

2025-10-01

Abstract excerpt

<h4>ABSTRACT</h4> Primary graft dysfunction (PGD) is a leading cause of early mortality after lung transplantation and is driven by ischemia-reperfusion injury (IRI), which destabilizes the pulmonary endothelium. Bone morphogenetic protein 9 (BMP9), a vascular quiescence factor of the TGF superfamily, maintains endothelial homeostasis through ALK-1/BMPR2-mediated signaling. Herein, this work identified a previous...

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Literature Corpus work: d948ab06-29a8-52aa-bec1-2ab1139c68ec
DOI: 10.1101/2025.09.30.679530

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