Article

A neuron-specific microexon ablates the novel DNA-binding function of a histone H3K4me0 reader PHF21A

2023-10-21

Abstract excerpt

How cell-type-specific chromatin landscapes emerge and progress during metazoan ontogenesis remains an important question. Transcription factors are expressed in a cell-type-specific manner and recruit chromatin-regulatory machinery to specific genomic loci. In contrast, chromatin-regulatory proteins are expressed broadly and are assumed to exert the same intrinsic function across cell types. However, human geneti...

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Literature Corpus work: d91f8c1f-87d6-533d-8220-96e588c3a4ae
DOI: 10.1101/2023.10.20.563357

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