Article

Asynchronous microexon splicing of <i>LSD1</i> and <i>PHF21A</i> during neurodevelopment

2024-03-21

Abstract excerpt

LSD1 histone H3K4 demethylase and its binding partner PHF21A, a reader protein for unmethylated H3K4, both undergo neuron-specific microexon splicing. The LSD1 neuronal microexon weakens H3K4 demethylation activity and can alter the substrate specificity to H3K9 or H4K20. Meanwhile, the PHF21A neuronal microexon interferes with nucleosome binding. However, the temporal expression patterns of LSD1 and PHF21A splici...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8d0177a-2235-505c-95f3-2835a849026e
DOI: 10.1101/2024.03.21.586181

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Asynchronous microexon splicing of <i>LSD1</i> and <i>PHF21A</i> during neurodevelopmentDOI 10.1101/2024.03.21.586181Read

A neuron-specific microexon ablates the novel DNA-binding function of a histone H3K4me0 reader PHF21ASemantic proximity Read

Intronic elements associated with insomnia and restless legs syndrome exhibit cell type-specific epigenetic features contributing to <i>MEIS1</i> regulationSemantic proximity Read

Mini-heterochromatin domains constrain the <i>cis</i> -regulatory impact of SVA transposons in human brain development and diseaseSemantic proximity Read

Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastomaSemantic proximity Read

The CoREST/REST Repressor Is both Necessary and Inimical for Expression of Herpes Simplex Virus GenesSemantic proximity Read

SUMOylation of nuclear receptor Nor1/NR4A3 coordinates microtubule cytoskeletal dynamics and stability in neuronal cellsSemantic proximity Read

Splicing- and demethylase-independent functions of LSD1 in zebrafish primitive hematopoiesis.Semantic proximity Read

Multi-layered regulatory networks driving human dopaminergic neuron differentiationSemantic proximity Read