Article

HIF-1α/LAPTM5/STAT1 axis promotes the malignant progression of clear cell renal cell carcinoma

2023-10-13

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cell carcinoma with poor prognosis and high mortality. Mutation-mediated inactivation of Von Hippel Lindau (VHL) is a hallmark feature of ccRCC, and it leads to the accumulation of hypoxia-inducible factors (HIFs) and cancer progression. Therefore, further elucidation of the network that regulates the VHL/HIF-1α pathway will provide potentia...

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Literature Corpus work: d91844fe-6d78-5317-bb0c-e59159ed355d
DOI: 10.21203/rs.3.rs-3300556/v1

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