Thyroid hormone induces B cells abnormal differentiation via overexpression of B cell-activating factor

Abstract excerpt

Breakdown of tolerance and abnormal activation in B cells is an important mechanism in Graves’ disease (GD) pathogenesis. However, the mechanism by which B cells are abnormal differentiated and activated in GD remains elusive. Here, we show that elevated BAFF expression is positively correlated with serum thyroid hormone (TH) levels in GD patients and high TH levels can induce BAFF overexpression and lead to the a...

Topics

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• Autoimmune Diseases
• B-Cell Activating Factor
• Case-Control Studies
• Gene Frequency
• Genetic Predisposition to Disease
• Graves Disease
• Hashimoto Disease
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

d9095d6c-46fd-5a29-8d50-594ca9f0e419

DOI

10.1101/2022.03.07.483380