Article
Frequency of mutations in PROP-1 gene in Turkish children with combined pituitary hormone deficiency.
The Turkish journal of pediatrics - 1 Jan 2000
Kandemir Nurgün, Vurallı Doğuş, Taşkıran Ekim, Gönç Nazlı, Özön Alev, Alikaşifoğlu Ayfer, Yılmaz Engin
Abstract excerpt
Mutations in the prophet of Pit-1 (PROP-1) gene are responsible for most of the cases of combined pituitary hormone deficiencies (CPHD). We performed this study to determine the prevalence of PROP-1 mutations in a group of Turkish children with CPHD. Fifty-three children with the diagnosis of CPHD were included in this study. Clinical data were obtained from medical files, and hormonal evaluation and genetic...
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