Article

The N-linker region of hERG1a upregulates hERG1b potassium channels

2021-12-22

Abstract excerpt

A major physiological role of hERG1 (human Ether-á-go-go-Related Gene) potassium channels is to repolarize cardiac action potentials. Two isoforms, hERG1a and hERG1b, associate to form the native cardiac I Kr current in vivo . Inherited mutations in hERG1a or hERG1b cause prolonged cardiac repolarization, Long QT Syndrome and sudden death arrhythmia. hERG1a subunits assemble with and enhance the number of hERG1b...

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Literature Corpus work: d8e98281-e220-50e0-88d7-bfa6f034209f
DOI: 10.1101/2021.12.20.473560

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