Article

Somatic mutations reveal hypermutable brains and are associated with neuropsychiatric disorders

2022-02-10

Abstract excerpt

Somatic mutations have causative roles in many diseases and contribute to neuropsychiatric disorders. Here, we analyzed 131 human brains (44 neurotypical, 19 with Tourette syndrome, 9 with schizophrenia, and 59 with autism) for somatic single nucleotide and structural mutations after whole genome sequencing to a depth of over 200X. Typically, brains had 20 to 60 detectable single nucleotide mutations that likely a...

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Literature Corpus work: d8e880cb-8d55-5da8-b6af-c6a52d120934
DOI: 10.1101/2022.02.09.22269114

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