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Article

Somatic mutations in the human brain: implications for psychiatric research.

Molecular psychiatry - 1 Jun 2019

Nishioka Masaki, Bundo Miki, Iwamoto Kazuya, Kato Tadafumi

Abstract excerpt

Psychiatric disorders such as schizophrenia and bipolar disorder are caused by complex gene-environment interactions. While recent advances in genomic technologies have enabled the identification of several risk variants for psychiatric conditions, including single-nucleotide variants and copy-number variations, these factors can explain only a portion of the liability to these disorders. Although non-inherited...

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Identifiers

PMID: 30087451
DOI: 10.1038/s41380-018-0129-y
PMCID: PMC6756205

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