Beneficial Outcome of Losartan Therapy Depends on Type of <i>FBN1</i> Mutation in Marfan Syndrome

Abstract excerpt

BACKGROUND: It has been shown that losartan reduces aortic dilatation in patients with Marfan syndrome. However, treatment response is highly variable. This study investigates losartan effectiveness in genetically classified subgroups. METHODS AND RESULTS: In this predefined substudy of COMPARE, Marfan patients were randomized to daily receive losartan 100 mg or no losartan. Aortic root dimensions were measured...

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