Article

Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy

2020-02-27

Abstract excerpt

<h4>Background and Purpose</h4> Immunosuppression is the predominant cause of mortality for sepsis due to failure to eradicate invading pathogens. Unfortunately, no effective and specific drugs capable of reversing immunosuppression are available for clinical use. Increasing evidence implicates vitamin D receptor (VDR) involved in sepsis-induced immunosuppression. Herein, artesunate (AS) was discovered to reverse...

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Literature Corpus work: 79ea5c16-c6df-5193-9a03-4cfa099e1782
DOI: 10.1101/2020.02.26.966143

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