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Single-Cell Transcriptomic Analysis Reveals Differential Cell Subpopulations and Distinct Phenotype Transition in Normal and Dissected Ascending Aorta

2022-06-13

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<title>Abstract</title> <p>Background Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain less studied. Methods Single-cell RNA sequencing was performed including 5 patients with ATAD and 4 healthy controls. Immunohistochemistry and immunofluorescence were use...

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Literature Corpus work: d8953adf-d99b-5056-9359-cd50f226542b
DOI: 10.21203/rs.3.rs-1655265/v1

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