Article
Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta.
Molecular medicine (Cambridge, Mass.) - 19 Dec 2022
He Yu-Bin, Jin Hai-Zhen, Zhao Jin-Long, Wang Chong, Ma Wen-Rui, Xing Jie, Zhang Xiao-Bin, Zhang Yang-Yang, Dai Huang-Dong, Zhao Nai-Shi, Zhang Jian-Feng, Zhang Guan-Xin, Zhang Jing
Abstract excerpt
BACKGROUND: Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain less studied. METHODS: Single-cell RNA sequencing was performed including 5 patients with ATAD and 4 healthy controls. Immunohistochemistry and immunofluorescence were used to verify the findings....
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