Article

Whole-blood transcriptomic traces of organ pathology and their causal triage

2026-08-03

Abstract excerpt

Whole blood offers a non-invasive window into organ health, yet it remains unclear which organ pathologies leave a detectable trace in the blood transcriptome, and whether such traces are causal or reactive. Progress has been limited because paired whole-blood profiles and pathologist-graded organ pathology are rarely available together. Here we assembled a pathology-linked benchmark of 59 pathologies across 20 or...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d89175d3-f890-5033-8798-4ca8684b9218
DOI: 10.64898/2026.07.31.26359425

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Whole-blood transcriptomic traces of organ pathology and their causal triageDOI 10.64898/2026.07.31.26359425Read

The landscape of plasma proteomic links to human organ imagingSemantic proximity Read

Tissue-aware interpretation of genetic variants advances the etiology of rare diseases.Semantic proximity Read

Analysis of biomarkers in the Human Phenotype Project using disease models from UK Biobank.Semantic proximity Read

PathQC: Determining Molecular and Physical Integrity of Tissues from Histopathological SlidesSemantic proximity Read

An atlas of human histological diversitySemantic proximity Read

Plasma-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systemsSemantic proximity Read

Cell Types of Origin in the Cell Free Transcriptome in Human Health and DiseaseSemantic proximity Read

A paired liver biopsy and plasma proteomics study reveals circulating biomarkers for alcohol-related liver diseaseSemantic proximity Read

Demarcating the Development of Cirrhosis and Its Complications via Plasma Proteomic Features in an Asymptomatic PopulationSemantic proximity Read

Histological aging signatures enable tissue-specific disease prediction from bloodSemantic proximity Read

Single-cell RNA-Seq data have prevalent blood contamination but can be rescued by Originator, a computational tool separating single-cell RNA-Seq by genetic and contextual informationSemantic proximity Read

A multi-omics approach combining causal inference and in vivo validation identifies key protein drivers of alcohol-associated liver disease.Semantic proximity Read