Article

Proteomic Analysis Defines Kinase Taxonomies Specific for Subtypes of Breast Cancer

2017-04-01

Abstract excerpt

Multiplexed small molecule inhibitors covalently bound to Sepharose beads (MIBs) were used to capture functional kinases in luminal, HER2-enriched and triple negative, basal-like and claudin-low breast cancer cell lines and tumors. Kinase MIB-binding profiles at baseline without perturbation proteomically distinguished the four breast cancer subtypes. Kinases lacking defined functions in breast cancer were highly...

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Literature Corpus work: d85f9235-5ae9-5d06-a196-3cc9948c1600
DOI: 10.1101/122739

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