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Integrative analysis of genomic and transcriptomic data informs precancer progression in the pancreas

2025-11-04

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) arises from heterogeneous precursor lesions, including intraductal papillary mucinous neoplasms (IPMNs), but the features distinguishing indolent from progressive lesions remain unclear. We performed an integrative analysis of transcriptomic, genomic, and microenvironmental profiles of IPMNs to define multi-omic phenotypes. Using transfer learning, we projected IPMN-derived...

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Literature Corpus work
77dd1812-e0a6-51dc-a5d0-1720169cc6d3
DOI
10.1101/2025.11.03.686234
Open publication

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Integrative analysis of genomic and transcriptomic data informs precancer progression in the pancreasDOI 10.1101/2025.11.03.686234
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