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Article

Early B cell changes predict autoimmunity following combination immune checkpoint blockade.

The Journal of clinical investigation - 1 Feb 2018

Das Rituparna, Bar Noffar, Ferreira Michelle, Newman Aaron M, Zhang Lin, Bailur Jithendra Kini, Bacchiocchi Antonella, Kluger Harriet, Wei Wei, Halaban Ruth, Sznol Mario, Dhodapkar Madhav V, Dhodapkar Kavita M

Abstract excerpt

Combination checkpoint blockade (CCB) targeting inhibitory CTLA4 and PD1 receptors holds promise for cancer therapy. Immune-related adverse events (IRAEs) remain a major obstacle for the optimal application of CCB in cancer. Here, we analyzed B cell changes in patients with melanoma following treatment with either anti-CTLA4 or anti-PD1, or in combination. CCB therapy led to changes in circulating B cells that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29309048
DOI: 10.1172/JCI96798
PMCID: PMC5785243

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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