Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fumarate induces vesicular release of mtDNA to drive innate immunity

8 Mar 2023

Abstract excerpt

Abstract Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma 1 . Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate 2 . However, although the long-term consequences of FH loss have been described, the acute response has not so far been investigated. Here we generated an inducible mouse model to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular vesicles in disease
Share to Ferroptosis and cancer prognosis
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36890229
DOI: 10.1038/s41586-023-05770-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fumarate induces vesicular release of mtDNA to drive innate immunityPMID 36890229Read ↗

STING and VDAC inhibitors attenuate inflammation and ineffective erythropoiesis caused by an altered metabolome in the <i>Nan</i> (EKLF/E339D) mouse model of neonatal anemiaSemantic proximity Read ↗

HIRA loss transforms FH-deficient cellsSemantic proximity Read ↗

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.Semantic proximity Read ↗

Hereditary Leiomyomatosis and Renal Cell Cancer: Recent Insights Into Mechanisms and Systemic TreatmentSemantic proximity Read ↗

Advances in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) research.Semantic proximity Read ↗

Gene of the month: FH.Semantic proximity Read ↗

FOXA2 controls the anti-oxidant response in FH-deficient cellsSemantic proximity Read ↗

Fumarate hydratase as a therapeutic target in renal cancerSemantic proximity Read ↗

IRF4 is a master regulator of multinucleated giant cell formationSemantic proximity Read ↗

Integrative genetic analysis identifies FLVCR1 as an essential component of choline transport in mammalsSemantic proximity Read ↗

Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction.Semantic proximity Read ↗

<i>MyD88</i> deficiency modestly attenuates disease in a Leigh syndrome mouse model while enrofloxacin accelerates diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.