Article

Defined neuronal populations drive fatal phenotype in Leigh Syndrome

2019-02-20

Abstract excerpt

Dysfunctions of the mitochondrial energy-generating machinery cause a series of progressive, untreatable and usually fatal diseases collectively known as mitochondrial disease. High energy-requiring organs such as the brain are especially affected, leading to developmental delay, ataxia, respiratory failure, hypotonia, seizures and premature death. While neural affectation is a critical component of the pathology,...

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Literature Corpus work: 8b64269a-ef47-554a-9943-f8a5c5ae3999
DOI: 10.1101/556019

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