Article

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

2024-06-06

Abstract excerpt

<title>Abstract</title> <p>Synovial Sarcoma (SS) is driven by the SS18::SSX fusion oncoprotein and is ultimately refractory to therapeutic approaches. SS18::SSX alters ATP-dependent chromatin remodeling BAF (mammalian SWI/SNF) complexes, leading to the degradation of canonical (cBAF) complex and amplified presence of an SS18::SSX-containing non-canonical BAF (ncBAF or GBAF) that drives an SS-specific transcriptio...

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Literature Corpus work: 8968e8c0-bd20-5af4-ae9b-1604ee8dc906
DOI: 10.21203/rs.3.rs-4362092/v1

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