Article

In vitro model for resistance in oncogene-dependent tumors at the limit of radiological detectability

2019-09-05

Abstract excerpt

In solid tumors, the response to targeted therapy is typically short-lived, as therapy-resistant mutants can quickly expand during therapy. Here we analyze the spectrum of such resistance mutations coexisting in a large population of cancer cells. We use an iterative scheme of artificial evolution to amplify and isolate different resistance mechanisms. As a proof of concept, we apply our scheme to PC-9 cells, a hu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d82f9ffc-580f-5cef-b3da-9e072e39050c
DOI: 10.1101/756593

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In vitro model for resistance in oncogene-dependent tumors at the limit of radiological detectabilityDOI 10.1101/756593Read

Mathematical Model of Intrinsic Drug Resistance in Lung Cancer.Semantic proximity Read

Drug resistance in cancer mechanisms and modelsSemantic proximity Read

Enigmas in tumor resistance to kinase inhibitors and calculation of the drug resistance index for cancer (DRIC).Semantic proximity Read

Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancerSemantic proximity Read

Drug resistance in cancer: Principles of emergence and preventionSemantic proximity Read

Understanding the Evolutionary Games in NSCLC MicroenvironmentSemantic proximity Read

Predicting Personalised Therapeutic Combinations in Non-Small Cell Lung Cancer Using In Silico ModellingSemantic proximity Read

A Nexus between Genetic and Non-Genetic Mechanisms Guides KRAS Inhibitor Resistance in Lung Cancer.Semantic proximity Read

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressuresSemantic proximity Read

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor <i>BRAF</i> gene mutations but lack mutations in <i>KRAS, NRAS,</i> or <i>MEK1</i>Semantic proximity Read

Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancerSemantic proximity Read

Characterizing Evolutionary Dynamics Reveals Strategies to Exhaust the Spectrum of Subclonal Resistance in EGFR-Mutant Lung Cancer.Semantic proximity Read