Article
A Nexus between Genetic and Non-Genetic Mechanisms Guides KRAS Inhibitor Resistance in Lung Cancer.
Biomolecules - 28 Oct 2023
Kulkarni Prakash, Mohanty Atish, Ramisetty Sravani, Duvivier Herbert, Khan Ajaz, Shrestha Sagun, Tan Tingting, Merla Amartej, El-Hajjaoui Michelle, Malhotra Jyoti, Singhal Sharad, Salgia Ravi
Abstract excerpt
Several studies in the last few years have determined that, in contrast to the prevailing dogma that drug resistance is simply due to Darwinian evolution-the selection of mutant clones in response to drug treatment-non-genetic changes can also lead to drug resistance whereby tolerant, reversible phenotypes are eventually relinquished by resistant, irreversible phenotypes. Here, using KRAS as a paradigm, we...
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