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Longitudinal Deep Multi-Omics Profiling in a <i> CLN3 <sup>Δex7/8</sup> </i> Minipig Model Reveals Novel Biomarker Signatures for Batten Disease

2023-09-22

Abstract excerpt

Development of therapies for CLN3 Batten disease, a rare pediatric lysosomal storage disorder, has been hindered by the lack of etiological insights and translatable biomarkers to clinics. Here, we used a deep multi-omics approach to discover new biomarkers using longitudinal serum samples from a porcine model of CLN3 disease. Comprehensive metabolomics was combined with a nanoparticle-based LC-MS-based proteomic...

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Literature Corpus work
d80952f4-df0a-511d-bb27-534ff2dcecc5
DOI
10.1101/2023.09.20.558629
Open publication

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Longitudinal Deep Multi-Omics Profiling in a <i> CLN3 <sup>Δex7/8</sup> </i> Minipig Model Reveals Novel Biomarker Signatures for Batten DiseaseDOI 10.1101/2023.09.20.558629
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