Distinct polyp recurrence timing and STK11 mutation status underlie clinical heterogeneity in pediatric Peutz-Jeghers syndrome.

doi:10.1002/jpn3.70376

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Article

Distinct polyp recurrence timing and STK11 mutation status underlie clinical heterogeneity in pediatric Peutz-Jeghers syndrome.

Journal of pediatric gastroenterology and nutrition - 1 Jun 2026

Yuan Lingzhi, Tong Qin, Xie Kang, Li Chengzhe, Wang Zhicheng, Hong Aomin, Tang Liyuan, You Jieyu, Ouyang Hongjuan, Liu Li, Zhang Wenting, Li Canlin, Zhan Meizheng, Jiang Na, Duan Jiaqi, Liu Chenxi, Zhou Juan, Wang Hua, Liu Jinqiao, Zhu Guanghui, Deng Yafei, Zhao Hongmei

Abstract excerpt

OBJECTIVES: Clinically, recurrent polyp growth is a characteristic feature of pediatric Peutz-Jeghers syndrome (PJS) patients. However, the clinical characteristics of pediatric PJS patients grouped by postoperative recurrence time remain undefined. Furthermore, differences in clinical features between serine/threonine kinase 11 (STK11)-positive and -negative patients, and the influence of STK11 mutation types on...

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PMID: 41810552
DOI: 10.1002/jpn3.70376

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STK11

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