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Article

Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

14 Jan 2011

Abstract excerpt

Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been linked to gene silencing and maintenance of chromosomal integrity. Using digital gene expression analysis, we showed that these transcripts are greatly overexpressed in mouse and human epithelial cancers. In 8 of 10 mouse pancreatic ductal adenocarcinomas (PDACs), pericentromeric satellites accounted for a mean 12% (range 1 to...

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PMID: 21233348
DOI: 10.1126/science.1200801

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