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Article

Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment.

Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2023

Miyata Kenichi, Zhou Xiangyu, Nishio Mika, Hanyu Aki, Chiba Masatomo, Kawasaki Hiroko, Osako Tomo, Takeuchi Kengo, Ohno Shinji, Ueno Takayuki, Maruyama Reo, Takahashi Akiko

Abstract excerpt

Cellular senescence and senescence-associated secretory phenotype (SASP) in stromal cells within the tumor microenvironment promote cancer progression. Although cellular senescence has been shown to induce changes in the higher-order chromatin structure and abnormal transcription of repetitive elements in the genome, the functional significance of these changes is unclear. In this study, we examined the human...

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Identifiers

PMID: 37523559
DOI: 10.1073/pnas.2305046120
PMCID: PMC10410700

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