Article

Functional maturation of human neural stem cells in a 3D bioengineered brain model enriched with fetal brain-derived matrix

2019-07-04

Abstract excerpt

Brain extracellular matrix (ECM) is often overlooked in vitro brain tissue models, despite its instructive roles during development. Using developmental stage-sourced brain ECM in reproducible 3D bioengineered culture systems, we demonstrate enhanced functional differentiation of human induced neural stem cells (hiNSCs) into healthy neurons and astrocytes. Particularly, fetal brain tissue-derived ECM supported lo...

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Literature Corpus work: 58fbd31b-9e8d-54d4-8ef7-20bfbb23f8f5
DOI: 10.1101/691907

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