ANGPTL3 binds to PCSK9 to coordinately regulate intracellular lipid homeostasis

Abstract excerpt

<h4>ABSTRACT</h4> ANGPTL3 and PCSK9 are core proteins involved in lipid metabolism. Literature evidence highlights a potential mutual regulation between them: patients harboring loss-of-function variants in ANGPTL3 show reduced levels of circulating PCSK9. After predicting their interaction using an in-silico model, we verified the direct interaction between ANGPTL3 and PCSK9 through co-immunoprecipitation. The A...

Topics

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• Angiopoietin-Like Protein 3
• Angiopoietin-like Proteins
• Cardiometabolic Risk Factors
• Genetic Predisposition to Disease
• Insulin Resistance
• Lipid Metabolism
• Molecular Targeted Therapy
• Mutation

Identifiers and source

Literature Corpus work

d7f04e5f-4750-5f94-9720-d7e8d240afc7

DOI

10.1101/2025.01.05.631413