Article
Molecular aspects of hypercholesterolemia treatment: current perspectives and hopes.
Annals of medicine - 1 Jun 2018
Ahangari Najmeh, Ghayour Mobarhan Majid, Sahebkar Amirhossein, Pasdar Alireza
Abstract excerpt
Hypercholesterolemia is a pathological condition which has been reported in 39% of the worlds' adult population. We aimed to review molecular aspects of current and novel therapeutic approaches based on low-density lipoprotein cholesterol lowering strategies. Pathogenic mutations in the LDLR, ApoB, PCSK9 and LDLRAP genes cause deficient clearance of circulating low-density lipoprotein cholesterol particles via...
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