Article

Human URAT1/ <i>SLC22A12</i> gene promoter is regulated by 27-hydroxycholesterol through estrogen response elements

2019-11-06

Abstract excerpt

Elevated levels of uric acid, a metabolite of purine in humans, is related to various diseases, such as gout, atherosclerosis and renal dysfunction. The excretion and reabsorption of uric acid to/from urine is tightly regulated by uric acid transporters. The amino acid sequences of uric acid reabsorption transporters, URAT1/ SLC22A12 , OAT4/ SLC22A11 , and OAT10/ SLC22A13 , share closer phylogenic relationship,...

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Literature Corpus work: d7c83793-1d66-5608-a8b7-7f329e8aebb4
DOI: 10.1101/827709

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