Article

Evaluating multiple next-generation sequencing derived tumor features to accurately predict DNA mismatch repair status

2022-06-21

Abstract excerpt

Identifying tumor DNA mismatch repair deficiency (dMMR) is important for precision medicine. We assessed tumor features, individually and in combination, in whole-exome sequenced (WES) colorectal cancers (CRCs) and in panel sequenced CRCs, endometrial cancers (ECs) and sebaceous skin tumors (SSTs) for their accuracy in detecting dMMR. CRCs (n=300) with WES, where MMR status was determined by immunohistochemistry,...

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Literature Corpus work: d79ed986-9ec0-51c3-af1a-ec82f2564c66
DOI: 10.1101/2022.06.20.22276419

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