Article

A 3D ovarian cancer metastasis model using a decellularized peritoneal matrix to study therapy response

2024-12-29

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) presents a significant therapeutic challenge. Late-stage disease is frequently associated with peritoneal carcinomatosis. The peritoneal metastases exhibit a unique tumor microenvironment (TME) distinct from the primary tumors and other metastatic sites. Understanding the critical influence of the extracellular matrix (ECM) in shaping the tumor phenotype is essential for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d790eb1a-2174-5aa2-a1b8-f3085c34ba5c
DOI: 10.1101/2024.12.27.24319681

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A 3D ovarian cancer metastasis model using a decellularized peritoneal matrix to study therapy responseDOI 10.1101/2024.12.27.24319681Read

Decellularized Normal and Tumor Extracellular Matrix as Scaffold for Cancer Organoid Cultures of Colorectal Peritoneal MetastasesSemantic proximity Read

Generation of an in vitro 3D multicellular culture model of ovarian high-grade serous carcinomaSemantic proximity Read

Tumoroid model recreates clinically relevant phenotypes of high grade serous ovarian cancer cells, carcinoma associated fibroblasts, and macrophages.Semantic proximity Read

Tumor microenvironment complexity and therapeutic implications at a glanceSemantic proximity Read

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma.Semantic proximity Read

Tumoroid model recreates clinically relevant phenotypes of high grade serous ovarian cancer (HGSC) cells, carcinoma associated fibroblasts, and macrophagesSemantic proximity Read

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinomaSemantic proximity Read

Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer MicroenvironmentSemantic proximity Read

Ascites-Driven Modulation of Cell Phenotypes and Proteomes: Implications for Cancer ProgressionSemantic proximity Read

Targeting the tumor stroma for cancer therapySemantic proximity Read

Establishment and its Utility of a Patient-Derived Cell Xenografts (PDCX) Model with Cryopreserved Cancer Cells from Human TumorSemantic proximity Read

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironmentsSemantic proximity Read