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Article

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma.

Scientific reports - 21 Apr 2020

De Thaye Elien, Van de Vijver Koen, Van der Meulen Joni, Taminau Joachim, Wagemans Glenn, Denys Hannelore, Van Dorpe Jo, Berx Geert, Ceelen Wim, Van Bocxlaer Jan, De Wever Olivier

Abstract excerpt

Peritoneal spread indicates poor prognosis in patients with serous ovarian carcinoma (SOC) and is generally treated by surgical cytoreduction and chemotherapy. Novel treatment options are urgently needed to improve patient outcome. Clinically relevant cell lines and patient-derived xenograft (PDX) models are of critical importance to therapeutic regimen evaluation. Here, a PDX model was established, by orthotopic...

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Share to Cystadenocarcinoma, Serous
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32317693
DOI: 10.1038/s41598-020-63738-6
PMCID: PMC7174384

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