TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis.

doi:10.1093/brain/awy062

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Article

TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis.

Brain : a journal of neurology - 1 May 2018

Deshaies Jade-Emmanuelle, Shkreta Lulzim, Moszczynski Alexander J, Sidibé Hadjara, Semmler Sabrina, Fouillen Aurélien, Bennett Estelle R, Bekenstein Uriya, Destroismaisons Laurie, Toutant Johanne, Delmotte Quentin, Volkening Kathryn, Stabile Stéphanie, Aulas Anaïs, Khalfallah Yousra, Soreq Hermona, Nanci Antonio, Strong Michael J, Chabot Benoit, Vande Velde Christine

Abstract excerpt

See Fratta and Isaacs (doi:10.1093/brain/awy091) for a scientific commentary on this article.The RNA binding proteins TDP-43 (encoded by TARDBP) and hnRNP A1 (HNRNPA1) are each mutated in certain amyotrophic lateral sclerosis cases and are often mislocalized in cytoplasmic aggregates within motor neurons of affected patients. Cytoplasmic inclusions of TDP-43, which are accompanied by a depletion of nuclear...

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Identifiers

PMID: 29562314
DOI: 10.1093/brain/awy062
PMCID: PMC5917749

Genes

HNRNPA1
TARDBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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