An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues

Abstract excerpt

Complex 3D bioengineered tumour models provide the opportunity to better capture the heterogeneity of patient tumours. Patient-derived organoids are emerging as a useful tool to study tumour heterogeneity and variation in patient responses. Organoid cultures typically require a 3D microenvironment that can be manufactured easily to facilitate screening. Here we set out to create a high-throughput, “off-the-shelf”...

Topics

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• Mice
• 3D Printing in Biomedical Research
• Cancer Cells and Metastasis
• Cell Culture Techniques
• Cell Survival
• Drug Evaluation, Preclinical
• High-Throughput Screening Assays
• Pancreatic and Hepatic Oncology Research

Identifiers and source

Literature Corpus work

d775d872-d0c4-5e5a-8a9d-8cc8f944128b

DOI

10.1101/2022.08.14.503643